The Federal University of Santa Maria (Portuguese: Universidade Federal de Santa Maria, UFSM) is a Brazilian public university located in Santa Maria, in the state of Rio Grande do Sul, funded by the federal government of Brazil. It was founded in 1960, by Professor José Mariano da Rocha Filho. Its campuses span over 1,837.72 ha, with a total of 386,968 m² of buildings and 28,307 students.

UFSM's presence in the municipality of Santa Maria is one of the reasons why the city is sometimes called university city or culture city. It is located in western Rio Grande do Sul, approximately 290 km far from the capital city of the state, Porto Alegre, thus being set in the heart of the pampas of Brazil.

As a public university, students do not pay tuition fees. It is the oldest federal university not located in a Brazilian state capital city, and the largest in number of undergraduate courses offered in Rio Grande do Sul state. As for 2015, the university was ranked at position 15 at national ranking from MEC.